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UID:18@tobaccocontrolnetwork.org
DTSTART;TZID=America/New_York:20240521T130000
DTEND;TZID=America/New_York:20240521T140000
DTSTAMP:20240223T015536Z
URL:https://tobaccocontrolnetwork.org/events/how-juul-reinvented-the-elect
 ronic-cigarette/
SUMMARY:How JUUL Reinvented the Electronic Cigarette
DESCRIPTION:Presenter: Richard D. Hurt\, M.D.\n\nOverview: Electronic ciga
 rettes entered the United States tobacco market in the early part of the 2
 1st century. The early e-cigarettes were modeled after the chemistry of co
 nventional cigarettes and were not efficient nicotine delivery devices. Th
 e e-liquid used “free base” nicotine that had adversive side effects. 
 In 2015\, JUUL launched and “re-invented” the e-cigarette\, by adding 
 benzoic acid to nicotine\, producing a salt nicotine. The company discover
 ed that by reconfiguring the formula of the e-liquid\, it produced equival
 ent blood nicotine levels as a conventional cigarette and thus had a simil
 ar addictive potential. This webinar will look at how the e-cigarette comp
 anies avoided FDA regulation\, helping them to compete in the tobacco mark
 et. It will also look at how nicotine in different forms play a role in ad
 diction.\n\nGoals and Objectives: \n\nAt the end of this presentation the
  attendees will be able to:\n\n 	Explain basic pharmacology of nicotine\, 
 its 3 forms (diprotonated\, mono protonated and unprotonated)\, and the ef
 fect of pH on the equilibrium and biologic availability of the forms.\n 	D
 escribe how conventional cigarettes are the most efficient nicotine delive
 ry devices ever conceived\, manufactured\, and perfected.\n 	Identify how 
 JUUL scientists and managers enhanced the nicotine delivery of its vaping 
 devices (utilizing knowledge about nicotine chemistry gleaned from previou
 sly secret tobacco industry documents) to emulate the delivery of conventi
 onal cigarettes and made the delivery of elevated levels of nicotine palat
 able.\n 	 Explain how JUUL promoted its device as a method to help smoker
 s “switch/stop” in the absence of randomized controlled trials to prov
 e safety and efficacy because it was more profitable to avoid regulation a
 s a medical product.\n
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